IS LIPOPEROXIDATION PLAYING A SIGNIFICANT CAUSATIVE ROLE IN ADRIAMYCIN-INDUCED CARDIOMYOPATHY ?
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چکیده
منابع مشابه
Preventive role of carvedilol in adriamycin-induced cardiomyopathy
BACKGROUND & OBJECTIVES Adriamycin though considered as an effective anticancer drug, leads to irreversible cardiomyopathy (CMP) and congestive heart failure (CHF). The aim of this study was to determine the protective effect of carvedilol in adriamycin (ADR)-induced cardiomyopathy (CMP) in cancer patients. METHODS Patients with lymphoreticular malignancy in whom ADR therapy was planned were ...
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Background—The precise molecular mechanism of Adriamycin-induced cardiomyopathy (ADR-CM) is still unknown. We address the demonstration of apoptotic myocardial cell death and the apoptosis-inducing molecules in ADR-CM induced in rats. Methods and Results—Until 8 weeks after the first administration of ADR, there was no increase in the number of labeled cells by terminal deoxynucleotidyl transfe...
متن کاملSheng-mai-san reduces adriamycin-induced cardiomyopathy in rats.
The traditional Chinese medicine prescription "sheng-mai-san (SMS)" has been used for treating patients with coronary heart disease for a long time and was found to have antioxidative effects. Here, we applied adriamycin (doxorubicin, ADR), a highly effective anticancer agent, as an inducer to establish the animal model of dose-related cardiomyopathy due to inhibition of nucleic acid as well as...
متن کاملImpact of ethyl pyruvate on Adriamycin-induced cardiomyopathy in rats
Ethyl pyruvate (EP), a derivative of pyruvic acid, is known to have protective effects against ischemic cardiomyopathy and other disorders. However, little is known about its role in Adriamycin (ADR)-induced cardiomyopathy. The present study was designed to investigate the impact of EP on ADR-induced cardiomyopathy in an animal model. Sixty male Sprague-Dawley (SD) rats were divided into four g...
متن کاملApoptosis and remodeling in adriamycin-induced cardiomyopathy rat model
Purpose The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apopt...
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ژورنال
عنوان ژورنال: The KITAKANTO Medical Journal
سال: 1984
ISSN: 0023-1908,1883-6135
DOI: 10.2974/kmj1951.34.47